TychoBio, an RNA therapeutics company located in Villejuif, Île-de-France, is using products from Integra Biosciences to streamline its high throughput oligonucleotide screening pipeline. The company generates large datasets and applies machine learning approaches to inform the design of better, safer and more efficient RNA therapies.
The core of TychoBio’s work is high throughput screening of oligonucleotide therapeutics, as Chief Scientific Officer Mathurin Dorel explained: “We screen lots of molecules: some are candidate therapeutics, while others are designed to gain information into how RNA is regulated. Our goal is to build a model that understands RNA regulation and can help us to design better therapeutics.”
The TychoBio team relies on the VacuSafe safe aspiration system and Switch hybrid pipettes to help them perform their vital research, improving throughput and saving time while ensuring safe and controlled aspiration of potentially hazardous liquids. “We use the VacuSafe to speed up routine processes, including removing media and washing of cells. The whole product is very easy to handle, you just plug it in and it works. If you are working with five or six plates at a time, it is a really convenient way to get rid of all the liquids from a 96 well plate rapidly. Without it, we’d be doing the task by hand with a multichannel pipette, so it probably saves each of us at least 30 minutes a day. We also have several Switch hybrid pipettes that combine manual pipetting with a repeat dispense mode, and not having to switch between a dispenser and a normal pipette is really convenient. I’ve worked with Integra products throughout my career, and that made them a natural choice here at TychoBio,” Mathurin concluded.
(Photo courtesy of TychoBio France.)
